Dosimetry in Peptide radionuclide receptor therapy: a review.

نویسندگان

  • Marta Cremonesi
  • Mahila Ferrari
  • Lisa Bodei
  • Giampiero Tosi
  • Giovanni Paganelli
چکیده

The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.

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عنوان ژورنال:
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine

دوره 47 9  شماره 

صفحات  -

تاریخ انتشار 2006